Low dose metformin for prediabetes

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Learn about the benefits and effectiveness of low dose metformin for prediabetes, a condition that increases the risk of developing type 2 diabetes. Discover how this medication can help lower blood sugar levels and improve insulin sensitivity, potentially preventing or delaying the onset of diabetes.

Low Dose Metformin for Prediabetes

Prediabetes is a condition where blood sugar levels are higher than normal but not high enough to be classified as type 2 diabetes. It is estimated that over 84 million adults in the United States have prediabetes, and without intervention, many of them will go on to develop type 2 diabetes within 5 years. However, recent studies have shown that low dose metformin may be an effective treatment option for prediabetes.

Metformin is a medication commonly used to treat type 2 diabetes. It works by reducing the amount of glucose produced by the liver and increasing the sensitivity of muscle cells to insulin. In addition to its use in diabetes management, metformin has also been shown to have potential benefits in preventing or delaying the onset of type 2 diabetes in individuals with prediabetes.

A recent study published in the New England Journal of Medicine found that low dose metformin reduced the risk of developing type 2 diabetes by 31% in individuals with prediabetes.

The study, which involved over 3,000 participants, compared the effects of low dose metformin (500 mg twice daily) with placebo in individuals with prediabetes. The results showed that metformin was effective in reducing the risk of developing type 2 diabetes over a 3-year period. This finding suggests that low dose metformin could be a viable option for individuals with prediabetes who are at high risk of progressing to type 2 diabetes.

Overview of Prediabetes

Prediabetes is a condition that occurs when blood sugar levels are higher than normal but not high enough to be diagnosed as type 2 diabetes. It is often considered a precursor to diabetes and serves as a warning sign that individuals are at an increased risk of developing the disease.

Prediabetes is a common condition, affecting millions of people worldwide. According to the American Diabetes Association, approximately 88 million adults in the United States have prediabetes, and the majority of them are unaware of their condition. Without intervention, about 30% of people with prediabetes will develop type 2 diabetes within 5 years.

Risk Factors for Prediabetes

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Several risk factors increase the likelihood of developing prediabetes. These include:

  • Being overweight or obese
  • Lack of physical activity
  • Poor diet, high in processed foods and sugar
  • Family history of diabetes
  • High blood pressure
  • High cholesterol levels
  • Polycystic ovary syndrome (PCOS)
  • History of gestational diabetes

Diagnosis of Prediabetes

Prediabetes is typically diagnosed through blood tests that measure fasting blood sugar levels or an oral glucose tolerance test. The American Diabetes Association defines the following diagnostic criteria for prediabetes:

  • Fasting blood sugar level between 100 and 125 mg/dL (5.6 and 6.9 mmol/L)
  • Oral glucose tolerance test result between 140 and 199 mg/dL (7.8 and 11.0 mmol/L) two hours after drinking a glucose-rich solution
  • Hemoglobin A1c level between 5.7% and 6.4%

It is important to note that these criteria may vary slightly depending on the guidelines used by different healthcare organizations.

Management of Prediabetes

Early intervention is crucial in managing prediabetes and preventing its progression to type 2 diabetes. Lifestyle modifications are the first line of treatment and include:

  • Healthy eating: Following a balanced diet that is low in processed foods, sugars, and saturated fats.
  • Regular physical activity: Engaging in at least 150 minutes of moderate-intensity aerobic exercise or 75 minutes of vigorous-intensity aerobic exercise per week.
  • Weight loss: Achieving and maintaining a healthy body weight through a combination of diet and exercise.
  • Quitting smoking: Smoking cessation can improve insulin sensitivity and reduce the risk of developing diabetes.

In addition to lifestyle modifications, some individuals with prediabetes may benefit from medication such as low-dose metformin. This oral medication is commonly used to treat type 2 diabetes and has been shown to help delay or prevent the onset of diabetes in high-risk individuals.

Conclusion

Prediabetes is a condition characterized by higher-than-normal blood sugar levels, indicating an increased risk of developing type 2 diabetes. It is important for individuals with prediabetes to make lifestyle changes and consider medical interventions to prevent the progression of the disease. Regular monitoring of blood sugar levels and working closely with healthcare professionals can help manage prediabetes effectively.

What is Prediabetes?

Prediabetes is a condition in which blood glucose levels are higher than normal, but not high enough to be classified as type 2 diabetes. It is often considered a precursor to developing diabetes, and if left untreated, can progress to type 2 diabetes within a few years. Prediabetes is a serious health condition that affects millions of people worldwide, and it is estimated that up to 70% of individuals with prediabetes will eventually develop diabetes.

There are several risk factors that can increase the likelihood of developing prediabetes, including being overweight or obese, having a family history of diabetes, being physically inactive, and having high blood pressure or high cholesterol levels. Additionally, certain ethnic groups, such as African Americans, Hispanics, and Native Americans, are at a higher risk for prediabetes.

Diagnosis of Prediabetes

Prediabetes is typically diagnosed through a blood test called the hemoglobin A1C test, which measures average blood glucose levels over the past 2-3 months. A hemoglobin A1C level between 5.7% and 6.4% is considered indicative of prediabetes. Another test that can be used to diagnose prediabetes is the fasting plasma glucose test, which measures blood glucose levels after fasting for at least 8 hours. A fasting plasma glucose level between 100 and 125 mg/dL is considered indicative of prediabetes.

Effects of Prediabetes

While prediabetes itself does not cause noticeable symptoms, it is a significant warning sign that the body is not effectively processing glucose and is at an increased risk for developing diabetes. If left untreated, prediabetes can lead to various complications, including an increased risk of heart disease, stroke, and kidney disease. It is important for individuals with prediabetes to take proactive steps to manage their condition and prevent the progression to diabetes.

Lifestyle Modifications for Prediabetes

One of the primary methods for managing prediabetes is through lifestyle modifications, including changes to diet and physical activity. A healthy diet that is low in processed sugars and carbohydrates, and high in fruits, vegetables, and lean proteins, can help regulate blood glucose levels and promote weight loss. Regular physical activity, such as brisk walking or cycling, can also improve insulin sensitivity and help maintain a healthy weight.

In addition to diet and exercise, individuals with prediabetes may also benefit from weight loss, smoking cessation, and stress management techniques. These lifestyle modifications can help improve overall health and reduce the risk of developing type 2 diabetes.

Prevalence of Prediabetes

Prediabetes is a condition characterized by blood glucose levels that are higher than normal but not high enough to be diagnosed as type 2 diabetes. According to the Centers for Disease Control and Prevention (CDC), prediabetes affects an estimated 88 million adults in the United States, which is more than one in three Americans. However, the majority of individuals with prediabetes are unaware of their condition.

The prevalence of prediabetes is increasing worldwide, largely due to the rising rates of obesity and sedentary lifestyles. It is a significant public health issue because if left untreated, prediabetes can progress to type 2 diabetes within 5-10 years. Additionally, individuals with prediabetes are at an increased risk of developing cardiovascular disease.

Risks and Consequences of Prediabetes

Prediabetes is a condition characterized by blood glucose levels that are higher than normal but not high enough to be classified as diabetes. It is often considered a precursor to type 2 diabetes and is a significant risk factor for developing the disease. If left untreated, prediabetes can lead to a variety of health complications and consequences.

One of the main risks of prediabetes is the progression to type 2 diabetes. Studies have shown that without intervention, up to 70% of individuals with prediabetes will develop diabetes within 10 years. Type 2 diabetes is a chronic condition that can lead to serious health problems, including heart disease, stroke, kidney disease, and nerve damage. Managing prediabetes through lifestyle changes and, in some cases, medication can help prevent or delay the onset of type 2 diabetes.

In addition to the increased risk of diabetes, prediabetes is associated with other health consequences. People with prediabetes are more likely to have high blood pressure and abnormal cholesterol levels, both of which are risk factors for heart disease. They are also at a higher risk for developing metabolic syndrome, a cluster of conditions that includes high blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels.

Furthermore, prediabetes can have a negative impact on overall quality of life. It can cause symptoms such as fatigue, increased thirst, frequent urination, and blurred vision. These symptoms can affect daily activities and well-being. Additionally, the psychological burden of knowing that one is at an increased risk for developing diabetes and other health complications can lead to anxiety and stress.

To mitigate the risks and consequences of prediabetes, lifestyle changes are recommended. These include adopting a healthy diet, increasing physical activity, losing weight if overweight or obese, and quitting smoking if applicable. These lifestyle modifications can help improve insulin sensitivity, lower blood glucose levels, and reduce the risk of developing diabetes and other associated health problems.

In some cases, medication may be prescribed to individuals with prediabetes to help lower their blood glucose levels. Metformin, a commonly prescribed medication for type 2 diabetes, has been shown to be effective in preventing or delaying the onset of diabetes in people with prediabetes. Low-dose metformin therapy is often used in these cases to help manage blood sugar levels and reduce the risk of progression to diabetes.

What is prediabetes?

Prediabetes is a condition in which blood sugar levels are higher than normal but not high enough to be diagnosed as diabetes. It is a warning sign that you may develop type 2 diabetes if you don’t make some lifestyle changes.

How is prediabetes diagnosed?

Prediabetes can be diagnosed through a blood test called the A1C test, which measures your average blood sugar level over the past three months. An A1C level between 5.7 and 6.4 percent is considered prediabetes.

What are the treatment options for prediabetes?

Treatment for prediabetes typically involves making lifestyle changes such as losing weight, eating a healthy diet, and exercising regularly. In some cases, medication such as metformin may also be prescribed to help lower blood sugar levels.

What is metformin?

Metformin is a medication commonly used to treat type 2 diabetes. It helps to lower blood sugar levels by reducing the amount of sugar produced by the liver and improving the body’s sensitivity to insulin.

Is metformin safe to use for prediabetes?

Yes, low dose metformin is generally safe to use for prediabetes. It has been shown to be effective in preventing or delaying the onset of type 2 diabetes in people with prediabetes. However, like any medication, it may have side effects and should be used under the guidance of a healthcare professional.

What is prediabetes?

Prediabetes is a condition in which blood sugar levels are higher than normal, but not high enough to be classified as type 2 diabetes. It is considered a warning sign that you may develop diabetes in the future.

What are the symptoms of prediabetes?

Prediabetes often does not have any noticeable symptoms. However, some people with prediabetes may experience increased thirst, frequent urination, fatigue, and blurred vision. It is important to get tested if you have any risk factors for prediabetes.

How is prediabetes diagnosed?

Prediabetes is diagnosed through blood tests that measure your fasting blood glucose levels, as well as your glucose levels after drinking a sugary solution. If your fasting blood glucose level is between 100 and 125 mg/dL, or your glucose level after the sugary solution is between 140 and 199 mg/dL, you may be diagnosed with prediabetes.

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(MORE) A TRIGGER MOMENT (2)

But, believe it or not, George Floyd’ money exchange scenario (especially, as I wrote it in the play) flashed before me – as he presented the cashier in his case a large bill, which in his case, was just a twenty dollar bill. Any way I gave her the C-note, held my breath and just hoped for the best. Now, I considered that I was surely over reacting. Because, I had just got this package of c-notes right from the bank. But continuing, the cashier accepted my c-note, frowning as she looked closely at it.

She thereupon held it closer to her eyes, frowning more. Then she would hold it overhead, towards the overhead light, (and squinting her) eyes. Next, she held it up and out towards the sun rays, coming through the large nearby windows

Oh my goodness, I thought,” let me tell this lady that I have the $41.00 in smaller bills, for her.”. But before I could get it out my mouth, she pivoted and left her drawer and station and walks three, (that’s right, three) whole aisle’s over.

“don’t tell me” I’m thinking, “she’s going after the dollar proofer contraption! And my goodness”, I reflected. “This is most unsettling. This is the very picture of what I imagined and actually wrote in my Saint George Floyd play.”

And she did exactly that! She ran it through, once while frowning, and then again, still frowning and nodding her head (negative) But, now, my girl, returns, and still with no words she deposits the funds beneath her drawer.

(Continued)
(MORE) A TRIGGER MOMENT (3)

Now, I knew my C-note was good, as I got it from the bank, but that didn’t ease this dreaded moment. Cause, who’s to say George Floyd’s paper wasn’t legit! And, now I know this story is getting long, and is already probably uncomfortable, but, I need you to feel my pain and dread, as I felt it. Or at least understand my feelings. And maybe, if possible, feel that I had a right to them.

But, back to the cashier, whom returns, without apology, counts out and hands me my change, with the receipt, smiles and turns for the next customer in line. I truly felt abused and was still concerned, and felt very much unsafe; not knowing if they (the machine) determined that the bill was a possible fake, and perhaps the police would appear to take me down at the door, or what?

And I thought upon my last trip to thos store, and the very same lady waited on me, and that evening, her not finding the sales ticket visible, she quickly threw my item under the counter, saying, that it wasn’t priced, so she couldn’t sell it. But I advised her it was marked inside, which she found to be true.

But, getting back to today, I did, make it out the door, without being intercepted by law enforcement, But, I said, let me make it to the car before I break down in relief.

But, making it to the car, I wanted to make a cell phone call, but, I thought better, let’s me move out before a swat team corner me in, with overhead helicopters.

So, I left thankful for my freedom and life, until the next shopping engagement. I noticed that my head, neck and shirt was filled with perspiration.

(Continued)
(MORE) A TRIGGER MOMENT (4)

Now, you may wonder, was this a Macy or Bloomingdale. High end shop, I was shopping and followed around to protect the precious merchandise. No, ha, ha, This was a Salvation Army store. You know, like a goodwill, thrift shop. But, With Blacks, as prey, it’s not what they’re protecting, it’s who you are.

“don’t tell me” I’m thinking, “she’s going after the dollar proofer contraption! Oh my goodness”, I reflected. “This is most unsettling. This is the very picture of what I imagined and actually wrote in my Saint Georfe Floyd play!” Now, panicking, I thought again to holler, to get her attention, that I had some smaller bills, that she could try.

And I submit that this is an important work, one of the most significant of this millennium. As this work is significant on several fronts: spiritually, it opens up Scriptures and God’s Voice that is a Godsend, and oh, so, precious but rare. It also offers a comforting understanding of the continuity of Life beyond the Earth plane. It as well, and in the natural, highlights the burden Black households have to give the Race talk to their young charges.

And, in concluding, the cause and purpose of the writer initiating this piece, which was as a mission, is that Saint George Floyd’s sacrifice and it’s aftermath of goodwill not diminish nor be forgotten, but is ever before men.

Yet the chief catalyst of the story is by the writer is to keep “George Floyd’s story center front, that men can continue to face one another as Brothers and One in fairness, justice and equity.
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(More) A letter from a Blackman…

George Floyd still could have been any of us. 

Since then I’ve asked myself so many questions. How come the police hate us? Will I ever get to live a life free of fear, free of pain, and anger? But the question that scares me the most is, do I need to see a therapist? The answer to the last question is, probably. 

When soldiers go to war, some come back broken because of the devastation, destruction, and trauma they had to endure. It’s called PTSD, or post-traumatic stress disorder and it’s a serious condition. 

If you can have sympathy for a soldier’s pain, how come you have little for Black pain. Our trauma is just as real as anyone else’s and we never signed up for it. 

In 2007, Robert. T. Carter theorized that individuals of color who experience racially charged discrimination as traumatic and often generate responses similar to post-traumatic stress. This was known as Race-based traumatic stress. It’s defined as the traumatic response to stress following a racial encounter. 

Racial trauma can be experienced by an individual or by an entire community and can also come with a host of symptoms such as anxiety and depression, loss of appetite, nightmares, low self-esteem, etc. 

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BUT HOW IS GEORGE FLOYD A SAINT? (4 parts)

Part 1 – Speaking of Miracles 

“But, how is George Floyd a Saint?” Yes, this question was raised as soon as I brought the name and idea of the play up, and it still reverberates “But how is George Floyd a saint?” 

So, let’s look at this in today’s light. Today, Saints must have performed at least two verified miracles. Ok, so let’s consider George Floyd. Now, according to the Washington Post, in the less than two years of George Floyds passing – on the law perspective – over 150 pieces of legislation and laws have been passed (in America) corralling in police powers and potential abuse. (Miracle #1). 

And on the economic and equity side, American corporations have pledged over 50 billion dollars towards Black causes, justice and equity (miracle #2). And shortly after the video of George Floyd’s state sanctioned execution went world viral, major, street closing, demonstrations (of majority White marchers) went on for weeks in over 150 countries around the world (miracle #3). 

None of these three monumental accomplishments had ever been even partially met, before (in the four centuries of Black subjugation in America) nor was any even considered possible.  And I submit to all, each was nothing less than a miracle of God!

But, now, let’s detour, from Saint George Floyd and let’s consider our idea and imaginings of the Sacredness of the Saint’s ordinations process and our overall reverence and goodwill in the Sainthood process, the Holy See and council.

Part 2 – What’s Holy about the (Sainthood) Process?

But, what, if like me, you know or learn that many a pope and cardinals and their bastilles owned enslaved persons, and even participated in their sub-human treatment and also the trading of Black humans as chattel to raise money for the church growth, etc.. Just google ‘Popes and Cardinal’s that owned slaves / enslaved persons’. And you will be surprised, and hopefully hurt and dismayed. And, it’s not hidden knowledge. 

There’s a most recent story, from the New York Times, March 2022, noting how Georgetown University (a leading Catholic University) was admitting to commandeering enslaved persons for free labor to build much of its campus; a deed they now admit was wrong and immoral and are now pledging over 100 million dollars, to remedy, with more promised.  

Ok, so how does that believed sacredness of the Saint-hood look now? Oh, that’s the past, one can rationalize. Well, what about this; less than two years ago, the head of the Saint making department, in the Vatican, was charged with corruption and conspiracy in a most unholy scandal. See below from a recent NY Times article.

“Cardinal Giovanni Angelo Becciu, accused of embezzlement, abuse of office, witness tampering, is on trial with nine other defendants in a corruption trial that centers on a London realestate deal in which the Vatican lost millions, charges the defendants deny. Pope Francis demanded the cardinal’s resignation,as head of the department in charge of making saints, in September 2020”

New York Times 5/5/2022

Seems to me, doubters, should first turn their attention to reform, this historic and present evil cabal, which grossly dishonor the Sainthood and the truth of God’s nature. 

Part 3 – The Evils that came before

Ok, let’s take a further look back, on the character and moral fortitude of the early church leaders.  In another find, biblical scholars and ancient manuscript researchers have recently shared a most disturbing (to most true Christians and right minded persons) a papal executive pronouncement issued by Pope Nicholas V, in the mid 1400’s. It’s referred to as the ‘Doctrine of Discovery 1452, and it’s included below.

Now, this (Doctrine of Discovery 1452) was issued, less than 50 years before Columbus invaded the islands around the Americas (in 1492).

In this light, we can better understand the atrocities scholars have attributed to his mad band of merry men, against the hapless, peaceful, inhabitants of the lands they would happen upon. For, by the highest order, the pope, whom, in earlier days was accepted as part King and part God Messenger, this exposition orders were not a betterment of mankind or a ‘we come in peace, mission’ but to conquer and annihilate: “to invade, search out, capture, vanquish”, etc. 

And understand these (designated enemies) were faultless and were inhabitants of far-away distant lands, which they were not at war with or had no knowledge of. And here, by this executive order they are commanded to reduce the inhabitants (of their own land) to “perpetual slavery, and to seize everything movable and immovable”. 

Wow, does this sound like a Holy or Christ driven mission or priesthood? Then what of its ‘saints’? Well, the Scriptures answers that “if the root of the tree is rotted, the entire tree is” 

Part 4 – Is a Saint for Black Justice not needed?

It’s probably little known, but Saints aren’t generally bestowed upon the overall church – but bestowed upon a cause, which is observed and needing certain help or hope. 

And now see, as there are hundreds of Saint’s, for just about any cause or group. ‘Saints for orphans’ ‘Saints for women’s Freedom’ ‘Saints of the down trodden’ ‘Saints for healing’, etc. So, see since Saints have specific duties and assigned groups and being that George Floyd, has brought such a massive influx of laws for equal justice and a great transition for economic parity for the Black race, except for bias, or unawareness, how isn’t he a Saint for Black justice, liberty and equity?

So, to the question, “how is George Floyd a saint? I ask you, even as I ask all, except perhaps in the mind of the bias, the ignorant or unaware, “how is George Floyd not a Saint?”

Here are just a few national articles (on the phenomenal Justice and economic Initiatives and impact) towards the Black race in America post George Floyd:

Mckinsey report / Mckinsey.com

‘The Opportunity to Advance Racial Equity’

NBC News / nbcnews.com 

‘Monumental impact of George Floyd’s death on Black America’

Washington Post / washingtonpost.com

‘Corporate America’s 50 billion promise’

Time Magazine / time.com

America since promises of the George Floyd protests

MORE ON – SUMMARY

Praise the Lord and pass the Blessings. This play ‘SAINT GEORGE FLOYD’ besides a vehicle of great entertainment, featuring: song, dance, art, video highlights and poems is foremost a celebration of George Floyd’s Life and Legacy, but it’s also an entity of renowned spiritual sharing. And it offers, that George Floyd did indeed “touched the world”, even as he promised – as humanity worldwide joined for the cause of ‘life, liberty and justice’ for all. 

The Mission and Purpose is Great!

And it’s about our survival (nothing less)

as Free Persons with equal Citizen Rights 

And, this is the writer’s mission, that Saint George Floyd’s sacrifice (and it’s aftermath of goodwill) not diminish nor is forgotten – but is ever before men and is multiplied -and that all men join together, in brotherhood. 

The Principle Story

Our story essentially is the chronicles of one day – (George Floyd’s last earth day – and his heavenly sojourn. Now, the (principle) story, in the story takes place on the second anniversary of George Floyd’s demise. 

Surely, it’s a story that’s not singular in nature; as it’s of a dutiful Black Father (of two young off-springs) just after the youths viewed a news replay of the (two years old) tragedy. Now, this Dad, as his peers, is compelled to deliver the Race / and George Floyd talk. (Thus, begins the ‘Saint George Floyd’ story).

God was in the Plan

Yet, this is a tale of grace and fantasy, not fatalism. It’s a comforting tale of hope and God’s gracious love. And we find that God Almighty was in the plan all along. As a Scripture reads “Man meant it for evil, but God meant it for good” And, the greater of this works takes place beyond the Veil – in the heavenly realm, even where he’s anointed ‘Saint George Floyd’. 

And in this heavenly aisle, Saint George Floyd, meets three of his most desired figures – and new guides: first his Mom, secondly, Jesus the Christ, and the third, the celebrated, Doctor Martin Luther King Jr. And as these share (comfort inspiration and Truth) with our subject, we’re also beneficiaries.

A Prayer for the Race

And it’s our ardent prayer, that – this vehicle might be an influence to help keep these newfound doors of goodwill, recently, extended to the darker skinned, open. While we readily, acknowledge, this effort is just a part, and of no great effect without the work and prayers of you and the collective. Yes, everyone and every fiber of our being, must move towards FREEDOM AND JUSTICE NOW!

MORE ON - WARREN AVERY

Warren’s latest book, as are several of his, is a book on Spirituality. It’s named ‘The Dynamic Truth of Being’. And its small audience, unanimously, touts it as a spiritual masterpiece. And Warren gives all the glory and praise to the Most High. His other spiritual books are ‘Teach Us to Pray ’The Spirit’ ‘Working on the Christ’ ‘But I say Unto you. And he’s even working on one now entitled ‘The Spirit speak’

Mr. Avery has also served as an instructor of Creative Writing and concept development in several educational and creative capacities.

And now Mr. Avery brings all his creative gifts, spirituality and love to the Saint George Floyd play / project, where he insists this one is a duty, and that in this, he’s truly “On a Mission from God’. 

MORE ON – LEIA AVERY

Co–creator, LEIA AVERY, is seemingly a born creative and business minded young female millennium. We can probably say it’s in her genes. She has shared that at 8 or 9 years of age, she set up a replica of ‘Bozo’s grand prize (bucket) game’ and others in her backyard and charged her friends and neighbors (their allowance) to play the games – they in fun and in hopes of winning some prizes. 

Now, as head of Just Play Entertainment, Leia is still about creating fun moments and activities. As Just Play caters to all – any size party or group: adults, students, families and even corporations. And Just Play’s (true to life) motto is “Never Stop Having Fun!” So you can see, Leia is on a roll and Leia plays to win. 

Leia as well has been an owner of a few small businesses and also Real Estate parcels. 

And now she gladly shares her various expertise and creativity in the production and promotion of the Saint George Floyd Musical Play and SGFmovement.com.